Researchers at King’s College in London have discovered that the drug Tideglusib is able to stimulate the renewal of stem cells found in the pulp of teeth. This allowed them to generate the mineralized material beneath the enamel, called dentin.
Whenever an amalgam needs to be redone or an infection occurs, the dentist must remove and fill an area larger than the one initially affected. After several treatments, you may need to pull out the tooth and replace it with an implant or bridge.
The team discovered new developments in their research and found that teeth could also be repaired with unexposed pulp, which is the most common form of caries.
If decay or trauma damages our teeth, three layers may be affected; the outer enamel, the intermediate layer of dentine and the dental pulp which is inside the tooth. The researchers had previously found that Tideglusib protected the third layer where the flesh was exposed by stimulating dentin production.
In the last study, the team discovered that the method also worked on the second layer where the pulp is not exposed, by increasing the natural secretion of reactionary dentin.
“At the beginning of the year, we showed that we could stimulate natural tooth repair by activating resident dental stem cells. This approach, which is simple and cost-effective, was used in teeth that had the vital layer (dental pulp) of the tooth exposed to the external environment, “said Professor Paul Sharpe, Director of the Center for Craniofacial and Regenerative Biology at King College London.
“We have now shown that this same approach can be used in shallow dentin lesion situations where differentiated cells (not stem cells) require activation. This type of injury is the most common case that dentists see in dental practice. “
These new results could pave the way for breakthrough new clinical products.
“By showing that we can use small molecules for the activation of Wnt / β-catenin signaling after superficial and deep tooth injury, we open doors to fabricate materials that naturally trigger dental pulp repair. Says Vitor Neves, a PhD student at the Dental Institute at King’s College London.
“Reinforced dentine would protect the pulp against irreversible pulpitis, which means that small cavities could be stopped before they turn into more serious problems, where root canals or tooth extractions are needed. “
In the previous study, biodegradable collagen sponges provided treatment and proved that small molecule drugs could penetrate the dentin to reach the targeted cells found in the pulp. Currently, the team is working on a new delivery system because collagen sponges can not be adapted to clinical delivery in the affected area in this case.
The natural remedy thus triggered has the advantage of not weakening the tooth, unlike the use of fillings, which do not consist of naturally occurring materials in the tooth structure and can therefore weaken the latter.
The drug could do without a number of clinical tests
Already clinically tested as part of its action against Alzheimer’s disease, the drug will be able to do without a number of clinical tests and thus arrive more quickly on the market, says The Guardian.
It relieves many patients because, as the lead author of the study, Paul Sharpe, puts it, “almost every human being on the planet is decayed at one time or another. The number of people treated is gigantic »
These dental discoveries are exactly what we need, mainly because in many countries dental insurance usually covers only half of the total costs. (source)